Securing Software-as-a-Service (SaaS) applications requires a multi-layered approach to protect sensitive data, prevent unauthorized access, and ensure compliance. Key strategies include implementing strong identity and access management (IAM) with multi-factor authentication (MFA), enforcing least privilege access, encrypting data in transit and at rest, and continuously monitoring for threats. Leveraging Zero Trust principles, security automation, and regular compliance audits further strengthens SaaS security. By adopting these best practices, organizations can mitigate risks and safeguard their cloud-based applications from evolving cyber threats.